mesangial expansion

HRI may have important effects on the renal structure by reducing glomerular mesangial cell proliferation, monocyte infiltration and mesangial matrix expansion.

该类药物可减轻肾小球系膜细胞增生，减少单核巨噬细胞浸润和细胞外基质蓄积。

Conclusions Accompanied with the antihypertensive effect, the inhibition to the mesangial expansion was shown by Cozaar.

结论科素亚在降低动脉压同时，有效地保护了肾脏，抑制高血压肾小球系膜细胞增生及系膜区扩张。

The action of ODNs on MC proliferation and mesangial matrix expansion was evaluated with quantitative pathologic analysis.

用定量病理分析方法观察反义、正义，错配寡核苷酸对系膜细胞和系膜基质增生的作用。

Results: After 8 weeks of YSR treatment, glycemia and glycosylated hemoglobin decreased, urinary microalbumin, kidney weight/ body weight and glomerular mesangial expansion were suppressed.

结果：益肾方治疗8周后，糖尿病大鼠的血糖、糖化血红蛋白明显降低，尿微量白蛋白排出减少，肾脏肥大及肾小球系膜基质增多减轻，其作用随剂量增大而增强。

Conclusions The accumulation of glomerular extracellular matrix which leads to mesangial expansion and glomerular hypertrophy can be completely prevented by 12 week C peptide treatment independent of metabolic control in STZ rats. But there is no prevention effect on whole kidney hypertrophy and leakage of urinary albumin.

结论单独应用C肽12周可以预防STZ大鼠肾小球细胞外基质积聚导致的系膜扩张和肾小球肥大，且不依赖糖代谢紊乱的纠正，但对整个肾脏肥大和尿白蛋白漏出没有预防作用。

These results suggest that abnormal production and activation of TGF β do exist in the glomerulus and mesangial cells under high glucose conditions. TGF β may be involved in the development of mesangial expansion during diabetic nephropathy.

结果表明高糖环境下肾小球和系膜细胞确实存在着TGFβ分泌和激活的异常，TGFβ可能参与了糖尿病肾病系膜区扩张的形成。